[Preventive use of nitrofurantoin in recurrent urinary tract infections]

51 patients suffering from chronic urinary tract infection were treated from 6 to 12 months with a single evening dose of 100 mg nitrofurantoin. The frequency of re-infection in the treatment period was compared with the same period before onset of therapy. The number of such re-infections was reduced significantly. Side effects of this therapy were substantial lower than after a three-times application per day. Gastrointestinal symptoms could be reduced in more than 50% of the cases by a combined therapy of 100 mg nitrofurantoin and 20 mg vitamin B6.