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Updated: Dec 21, 2025

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
Analysis of flow field and hemolysis index in axial flow blood pump by computational fluid dynamics-discrete element
Lizhi Cheng1,2, Jianping Tan1, Zhong Yun1
1School of Mechanical and Electrical Engineering, Central South University, Changsha, China.
Abstract:
To fully study the relationship between the internal flow field and hemolysis index in an axial flow blood pump, a computational fluid dynamics-discrete element method coupled calculation method was used. Through numerical analysis under conditions of 6000, 8000, and 10,000 r/min, it was found that there was flow separation of blood cell particles in the tip of the impeller and the guide vane behind the impeller. The flow field has a larger pressure gradient distribution, which reduces the lift ratio of the blood pump and easily causes blood cell damage. The study shows that the hemolysis index obtained by the computational fluid dynamics-discrete element method is 4.75% higher than that from the traditional computational fluid dynamics method, which indicates the impact of microcollision between erythrocyte particles and walls on hemolysis index and also further verifies the validity of the computational fluid dynamics-discrete element coupling method. Through the hydraulic and particle image velocimetry experiments of the blood pump, the coincidence between numerical calculation and experiment is analyzed from macro and micro aspects, which shows that the numerical calculation method is feasible.
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