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Manifestations of left ventricular dysfunction and arrhythmia in patients with chronic hypoparathyroidism and

Yabing Wang1, Kun He2, Ou Wang1

  • 1Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Dongcheng District, Shuaifuyuan No.1, Beijing, 100730, China.

BMC Endocrine Disorders
|May 13, 2020
PubMed

Insights

Patients with hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) show normal cardiac structure and function. However, prolonged QTc intervals and mild arrhythmias may occur, warranting further investigation in these chronic conditions.

Area of Science:

  • Cardiology
  • Endocrinology
  • Genetics

Background:

  • Severe hypocalcemia is known to cause cardiac damage.
  • The cardiac implications of chronic hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) remain under-explored.
  • This study investigates the cardiac effects in treated HP and PHP patients.

Purpose of the Study:

  • To assess cardiac structure and conductive function in patients with chronic hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP).
  • To compare cardiac parameters between patients and healthy controls.

Main Methods:

  • Included 18 HP patients and 8 PHP patients, plus 26 healthy controls.
  • Assessed cardiac function and structure via myocardial enzymes, BNP, echocardiography.
  • Evaluated electrical conduction using 12-lead ECG and 24-h Holter monitoring.

Main Results:

  • Serum calcium levels were within the normal range for HP and PHP patients.
  • Myocardial enzyme and BNP levels were normal.
  • Cardiac morphology (LVM, LVMI, RWT) and ventricular function were comparable to controls.
  • Prolonged QTc intervals observed in 52.6% of patients.
  • Mild arrhythmias (extrasystoles, SVT) noted in a small percentage of patients, without severe clinical events.

Conclusions:

  • Well-controlled HP and PHP patients exhibit normal cardiac morphology and ventricular function.
  • Prolonged QTc intervals and mild arrhythmias are potential findings in these patients.
  • Further research is needed to investigate these cardiac electrical abnormalities.
Abstract

Keywords:
ArrhythmiaFunctionHeartHypoparathyroidismPseudohypoparathyroidism

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