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Altered behavior in mice overexpressing soluble ST2.

Motoshi Kikuchi1, Kenkichi Takase2, Morisada Hayakawa3

  • 1Laboratory of Natural History, Jichi Medical University School of Medicine, Tochigi, Japan.

Molecular Brain
|May 13, 2020
PubMed
Summary

Overexpression of soluble ST2 (sST2) in mice led to reduced social interaction and increased depression-like behaviors, suggesting sST2

Keywords:
DepressionForced swimming testMouseSoluble ST2Tail suspension test

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Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Psychoneuroimmunology links immunity to depression.
  • Soluble ST2 (sST2) is a key immune regulator implicated in neuropsychiatric disorders.
  • The role of sST2 in depressive behavior is not fully understood.

Purpose of the Study:

  • To investigate the role of soluble ST2 (sST2) in depressive behavior using a transgenic mouse model.
  • To establish an animal model for studying sST2 in neuropsychiatric disorders.

Main Methods:

  • Generated transgenic mice overexpressing soluble ST2 (ST2 Tg mice).
  • Conducted comprehensive behavioral phenotyping, including sensorimotor, anxiety, depression, social, and learning/memory tests.
  • Utilized a depression test battery (two-bottle choice, forced swimming, tail suspension tests).

Main Results:

  • ST2 Tg mice exhibited normal general health and neurological reflexes.
  • Overexpression of sST2 resulted in decreased social interaction.
  • ST2 Tg mice showed depression-like behaviors in forced swimming and tail suspension tests.
  • Hedonic responses to sucrose remained intact in ST2 Tg mice.

Conclusions:

  • Established a ST2 Tg mouse model for assessing sST2's role in neuropsychiatric disorders.
  • Demonstrated that sST2 overexpression is associated with depression-like behaviors and social deficits.
  • Suggests a potential involvement of sST2 in the pathophysiology of depression.