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Updated: Dec 21, 2025

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
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The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance

Margot Riggi1,2,3, Beata Kusmider1,3, Robbie Loewith4,3

  • 1Swiss National Centre for Competence in Research Program Chemical Biology, Geneva, Switzerland.

Journal of Cell Science
|May 13, 2020
PubMed

Insights

Target of rapamycin complex 2 (TORC2) regulates cell surface homeostasis. Recent studies in yeast highlight TORC2

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Target of rapamycin (TOR) is a conserved kinase regulating cellular processes.
  • TOR forms two complexes: TORC1 and TORC2, with distinct functions.
  • TORC1 regulates cell growth and homeostasis; TORC2 functions are less understood.

Purpose of the Study:

  • To review recent advances in understanding TORC2 signaling.
  • To highlight TORC2's role in cell surface homeostasis, particularly in yeast.

Main Methods:

  • Literature review of recent studies on TORC2 signaling.
  • Focus on findings from yeast models.

Main Results:

  • TORC2 is emerging as a key regulator of cell surface homeostasis.
  • Studies in yeast provide significant insights into TORC2 functions.

Conclusions:

  • TORC2 plays a critical role in maintaining cell surface integrity.
  • Further research into TORC2 signaling pathways is warranted.
Keywords:
Membrane tension homeostasisProtein kinaseSignallingTORC2

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