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The emerging roles of WBP2 oncogene in human cancers

Hossein Tabatabaeian1,2, Angad Rao2, Alisha Ramos2

  • 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

Oncogene
|May 13, 2020
PubMed

Insights

WW domain-binding protein 2 (WBP2) is an oncoprotein linking key cancer pathways. Research explores WBP2

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • WW domain-binding protein 2 (WBP2) is increasingly recognized as a significant oncoprotein.
  • WBP2 acts as a central regulator, connecting critical signaling pathways such as ER/PR, EGFR, PI3K, Hippo, and Wnt in various cancers.

Purpose of the Study:

  • To review the latest research on the multilevel regulation and mechanisms of action of WBP2.
  • To explore the potential of WBP2 in molecular medicine and targeted cancer therapies.
  • To highlight WBP2's role as a biomarker in breast cancer for early detection, prognosis, and companion diagnostics.

Main Methods:

  • Literature review of recent studies on WBP2.
  • Analysis of WBP2's role in cancer signaling pathways.
  • Evaluation of translational research data regarding WBP2 as a biomarker.

Main Results:

  • WBP2 integrates multiple oncogenic signaling pathways crucial for cancer development.
  • Evidence supports WBP2's utility as a biomarker for breast cancer diagnosis and prognosis.
  • WBP2's functions can be targeted for novel therapeutic strategies.

Conclusions:

  • WBP2 is a key player in cancer etiology and progression.
  • Targeting WBP2 offers potential for developing new cancer therapeutics and precision medicine approaches.
  • Further research into WBP2's molecular mechanisms and clinical applications is warranted.

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