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The claustrum coordinates cortical slow-wave activity.

Kimiya Narikiyo1,2, Rumiko Mizuguchi1,3, Ayako Ajima1,2

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Nature Neuroscience
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The claustrum coordinates neocortical slow-wave (SW) activity by synchronizing inhibitory interneurons. Ablating these claustral neurons reduced SW activity, highlighting their crucial role in brain function.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neocortical slow-wave (SW) activity is generated during sleep and awake rest.
  • The precise mechanisms coordinating large-scale SW generation remain incompletely understood.

Purpose of the Study:

  • To investigate the role of the claustrum in coordinating neocortical SW activity.
  • To elucidate the function of a specific subpopulation of claustral glutamatergic neurons.

Main Methods:

  • Established a transgenic mouse line for genetic interrogation of claustral glutamatergic neurons.
  • Utilized in vitro and in vivo optogenetics to stimulate and ablate claustral neurons.
  • Recorded neuronal activity and postsynaptic responses in neocortical areas.

Main Results:

  • Claustral glutamatergic neurons project to and receive input from widespread neocortical areas.
  • Claustral neuronal firing correlates with cortical SW activity.
  • Optogenetic stimulation induced synchronized neural silencing and down-to-up state transitions in the cortex.
  • Genetic ablation of claustral neurons attenuated frontal cortical SW activity.

Conclusions:

  • The claustrum plays a crucial role in coordinating neocortical SW activity.
  • Claustral neurons synchronize inhibitory interneurons across cortical areas for spatiotemporal coordination of SWs.