COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients

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Georg Härter1, Christoph D Spinner2, Julia Roider3,4

  • 1Medicover Ulm MVZ, Münsterplatz 6, 89073, Ulm, Germany. ghaerter@gmx.de.

Infection
|May 13, 2020
PubMed

Insights

People living with HIV (PLWH) on antiretroviral treatment (ART) experienced mild COVID-19 outcomes. This study found no excess mortality in PLWH with suppressed viral loads, suggesting ART may be protective.

Area of Science:

  • Infectious Diseases
  • Virology
  • Immunology

Background:

  • Limited data exists on COVID-19 outcomes for people living with human immunodeficiency virus (PLWH).
  • This case series examines symptoms and outcomes in 33 PLWH patients diagnosed with COVID-19.

Purpose of the Study:

  • To investigate the clinical presentation and outcomes of COVID-19 in individuals living with HIV.
  • To assess potential excess morbidity and mortality in this population during the SARS-CoV-2 pandemic.

Main Methods:

  • Retrospective analysis of anonymized patient data.
  • Inclusion of demographic, HIV-associated parameters, symptoms, and outcome data.
  • Focus on patients on antiretroviral treatment (ART).

Main Results:

  • 91% of patients recovered from COVID-19, with 76% experiencing mild cases.
  • Mortality rate was 9% (3 out of 32 patients with documented outcomes).
  • All patients were on ART, with many on tenofovir-containing regimens or darunavir.

Conclusions:

  • Preliminary findings do not indicate excess morbidity or mortality for symptomatic COVID-19 PLWH with viral suppression on ART.
  • SARS-CoV-2 infection can occur in patients on boosted darunavir-based and/or tenofovir-containing ART.
Abstract

Keywords:
AIDSAntiretroviral therapyCOVID-19HIV infectionSARS-CoV-2

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