Related Experiment Video
Updated: Dec 21, 2025
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Association between the polymorphisms in MMP-2 and MMP-9 with adiposity and mammographic features
Suélène Georgina Dofara1, Sue-Ling Chang1, Caroline Diorio2
1Centre de Recherche du CHU de Québec-Université Laval (axe oncologie), Centre de Recherche sur le Cancer de L'Université Laval et Département de médecine Sociale et préventive, Faculté de médecine, Université Laval, 1050 Chemin Sainte-Foy, Quebec, QC, G1S 4L8, Canada.
Background:
Matrix metalloproteinases (MMP)-2 and -9 may play an important role in adipogenesis and carcinogenesis. We investigated whether some polymorphisms located in these genes are associated with body adiposity and mammographic breast density, which are risk factors for breast cancer.
Methods:
Our study population included 731 premenopausal women. Multivariate generalized linear models were used to evaluate the association of polymorphisms rs243865 in MMP-2 and rs3918242, rs17576, rs2250889 and rs2274756 in MMP-9 with anthropometric factors that refer to adiposity and mammographic features (percent density, dense area and non-dense area) measured by computer-assisted method.
Results:
The number of copies of rs243865 T allele in MMP-2 was associated with increased means of anthropometric factors (ptrend < 0.05 for all except waist-to-hip ratio). The same allele of rs243865 was associated with decreased mean percent density (ptrend = 0.036) and increased mean non-dense area (ptrend = 0.031) when adjusted for potential confounders, but these associations were attenuated when further adjusted for adiposity.
Conclusion:
These findings suggest that the relation between rs243865 in MMP-2 and mammographic features could be mediated by adiposity.
