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Mechanism of action of high-load copper IUDs
A de Castro1, P Gonzalez-Gancedo
1Hospital La Paz, Departamento de Obstetricia y Ginecologia, Madrid, Spain.
Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
|September 1, 1988
Abstract:
A comparative study was made of four intrauterine contraceptive devices: the Nova-T, MLCu250 Short, MLCu375, and the Gyne T. An endometrial biopsy was performed on the 25th day of the menstrual cycle. The tissue obtained was analyzed to determine estrogen and progesterone receptor concentration. After two years of IUD use, both estrogen and progesterone receptors decreased proportionally to the increased amount of copper in the IUD.