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Lipid-Coated Nanosized Drug Delivery Systems for an Effective Cancer Therapy
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Abstract:
Currently, despite many active compounds have been introduced to the treatment, cancer remains one of the most vital causes of mortality and reduced quality of life. Conventional cancer treatments may have undesirable consequences due to the continuous differentiating, dynamic and heterogeneous nature of cancer. Recent advances in the field of cancer treatment have promoted the development of several novel nanoformulations. Among them, the lipid coated nanosized drug delivery systems have gained an increasing attention by the researchers in this field owing to the attractive properties such as high stability and biocompatibility, prolonged circulation time, high drug loading capacity and superior in vivo efficacy. They possess the advantages of both the liposomes and polymeric nanoparticles which makes them a chosen one in the field of drug delivery and targeting. Core-shell type lipid-coated nanoparticle systems, which provide the most prominent advantages of both liposomes such as biocompatibility and polymeric/inorganic nanoparticles such as mechanic properties, offer a new approach to cancer treatment. This review discusses design and production procedures used to prepare lipid-coated nanoparticle drug delivery systems, their advantages and multifunctional role in cancer therapy and diagnosis, as well as the applications they have been used in.
Insights
Lipid-coated nanoparticles offer a promising new approach to cancer treatment, combining the benefits of liposomes and polymeric nanoparticles for enhanced drug delivery and efficacy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Cancer remains a leading cause of mortality, with conventional treatments facing limitations due to tumor heterogeneity.
- Novel nanoformulations are emerging as advanced cancer treatment strategies.
- Lipid-coated nanosized drug delivery systems are gaining attention for their unique properties.
Purpose of the Study:
- To review the design and production of lipid-coated nanoparticle drug delivery systems.
- To highlight the advantages and multifunctional roles of these systems in cancer therapy and diagnosis.
- To discuss their current applications in cancer treatment.
Main Methods:
- Review of current literature on lipid-coated nanoparticle synthesis.
- Analysis of nanoparticle properties including stability, biocompatibility, drug loading, and in vivo efficacy.
- Examination of applications in cancer therapy and diagnostics.
Main Results:
- Lipid-coated nanoparticles exhibit high stability, biocompatibility, prolonged circulation, and superior in vivo efficacy.
- These systems integrate the advantages of liposomes (biocompatibility) and polymeric/inorganic nanoparticles (mechanical properties).
- Core-shell lipid-coated nanoparticles present a novel approach for cancer treatment.
Conclusions:
- Lipid-coated nanoparticles are versatile platforms for advanced cancer therapy and diagnosis.
- Their design and production methods are crucial for optimizing therapeutic outcomes.
- Further research into their applications promises significant advancements in oncology.
