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Updated: Dec 21, 2025

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
Published on: November 2, 2020
[Focus on the Myocardial Hypertrophy from the Perspective of Transcriptomics and Metabolomics]
G A Shakaryants1, M V Kozhevnikova1, V Yu Kaplunova1
1I.M. Sechenov First Moscow State Medical University (Sechenov University).
Abstract:
This review presents major directions in studies of myocardial hypertrophy from the aspect of transcriptomics and metabolomics. Understanding of trigger mechanisms of myocardial hypertrophy will permit transition from basic studies to individualized clinical application of innovative technologies in the treatment of heart diseases, such as targeted therapy. At the present time, methods have been developed for diagnostics and prediction of cardiovascular diseases based on the metabolomic profiling and the evaluation of microRNA expression. Progress in studying molecular and genetic processes underlying the development of cardiovascular diseases may provide invaluable information for clinical cardiology.
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