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Shear wave elastography in diffuse thyroid disease.

Zuzana Sedlackova1, Jan Herman2, Tomas Furst1

  • 1Department of Radiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital, Olomouc, Czech Republic.

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|May 13, 2020
PubMed
Summary
This summary is machine-generated.

Shear wave elastography reveals that diffuse thyroid disease significantly increases thyroid gland stiffness. Minimal stiffness is lower in patients compared to healthy individuals, impacting diagnostic accuracy.

Keywords:
diffuse thyroid diseaseelastographyshear waveultrasound

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Area of Science:

  • Endocrinology
  • Medical Imaging
  • Rheology

Background:

  • Diffuse thyroid diseases encompass a range of conditions affecting thyroid gland function and structure.
  • Conventional ultrasound is a primary imaging modality, but assessing diffuse changes can be challenging.
  • Shear wave elastography (SWE) offers quantitative tissue stiffness measurements.

Purpose of the Study:

  • To evaluate the utility of shear wave elastography in assessing diffuse thyroid disease.
  • To quantify thyroid gland stiffness in patients with diffuse thyroid disease.
  • To compare thyroid stiffness between patients and healthy controls.

Main Methods:

  • 46 patients with diffuse thyroid disease underwent clinical examination, conventional ultrasound, and SWE.
  • Conventional ultrasound parameters included volume, margin quality, nodules, and vascularization.
  • SWE measured mean, minimum, and maximum stiffness, correlated with 128 healthy subjects.

Main Results:

  • Patients with diffuse thyroid disease exhibited significantly higher mean (12.5 ± 5 kPa) and maximal (35.3 ± 12.8 kPa) thyroid stiffness compared to controls (9.5 ± 3.6 kPa and 22.5 ± 7.3 kPa, respectively).
  • Minimal stiffness was significantly lower in patients (0.5 ± 0.6 kPa) than controls (2.2 ± 2.1 kPa).
  • Stiffness correlated positively with BMI and thyroid volume but not with margin quality, nodules, or vascularization.

Conclusions:

  • Mean and maximal thyroid gland stiffness are significantly elevated in diffuse thyroid disease.
  • Minimal thyroid stiffness is reduced in diffuse thyroid disease compared to healthy individuals.
  • SWE provides valuable quantitative data for diagnosing and characterizing diffuse thyroid disease.