Proximal ureteral reconstruction using renal capsule flap: a canine experimental model
Related Experiment Video
Updated: Dec 21, 2025
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
Published on: April 4, 2025
Seyed Masoud Zolhavarieh1, Shahriar Amirhassani2, Shahriar Sannamari2
1Department of Clinical Sciences, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.
Introduction:
The aim of this article was to evaluate the effectiveness of using the renal capsule in ureteral reconstruction in a canine model.
Material And Methods:
Ten clinically healthy male adult dogs were used in this study. Dogs underwent ureteral reconstruction using a tube-shaped flap of the renal capsule.
Results:
All but one animal (90%) survived till nephrectomy and thereafter. At 30 days after operation, the double-J stent was removed from the ureter, and at the 60th day, intravenous pyelography confirmed openness of the duct. The internal surface of the tunneled flap was coated with thick, folded urothelium. Maturing granulation tissue and angiogenesis as well as fiber producing fibroblasts were observed in the lamina propria. The presence of smooth muscle cells beneath the lamina propria indicated complete reconstitution of the damaged ureter.
Conclusions:
The results showed that the autologous renal capsular flap provided a practical option for treating ureteral defects in dogs with an acceptable outcome. So, using the selfsame renal capsular tissue is a feasible method for restoration of the injured proximal ureter.
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