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Updated: Dec 21, 2025
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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
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Pathogenicity of BK virus on the urinary system
Wojciech Krajewski1, Dorota Kamińska2, Adrian Poterek1
1Department of Urology and Oncological Urology, Wrocław Medical University, Wrocław, Poland.
Central European Journal of Urology
|May 13, 2020
Summary
BK virus, commonly latent, can reactivate in immunocompromised individuals, leading to serious kidney and bladder complications post-transplant. This review covers BK virus
Area of Science:
- Urology
- Virology
- Immunology
Background:
- BK virus is a ubiquitous polyomavirus.
- It primarily affects kidney tubular epithelial cells and bladder transitional cells.
Purpose of the Study:
- To review current data on the urologic aspects of BK virus infection.
- To discuss detection methods and available treatments for BK virus.
Main Methods:
- A comprehensive literature search was performed using Medline database.
- PRISMA guidelines were followed for the search.
- Keywords included 'BK virus' and urologic conditions like transplantation, nephropathy, and cystitis.
Main Results:
- BK virus typically remains latent but can reactivate in immunocompromised states.
- Post-transplant complications include polyomavirus-associated nephropathy (kidney transplant) and hemorrhagic cystitis (stem cell transplant).
Conclusions:
- BK virus poses significant risks in transplant recipients.
- Understanding its urologic manifestations, detection, and treatment is crucial.
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