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An Update on Current Therapeutic Drugs Treating COVID-19
Renyi Wu1, Lujing Wang1, Hsiao-Chen Dina Kuo1
1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.
Current Pharmacology Reports
|May 13, 2020
Summary
This review summarizes potential repurposed drugs for treating coronavirus disease 2019 (COVID-19) patients. It details antiviral and supportive agents to manage SARS-CoV-2 infection until vaccines are available.
Area of Science:
- Infectious Diseases
- Pharmacology
- Public Health
Background:
- The COVID-19 pandemic caused by SARS-CoV-2 presents global healthcare challenges.
- Effective vaccines and specific therapeutics for SARS-CoV-2 are currently unavailable.
- Clinical management relies on supportive care and infection control.
Purpose of the Study:
- To review and summarize common and plausible repurposed drugs for COVID-19 treatment.
- To provide an updated therapeutic drug list for managing SARS-CoV-2 infection.
- To offer interim treatment options pending vaccine and specific drug approval.
Main Methods:
- Literature review of evolving research and clinical data on SARS-CoV-2.
- Identification and summarization of repurposed drugs with potential therapeutic efficacy.
- Categorization of drugs into antiviral and supporting agents.
Main Results:
- Identified several antiviral agents including remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir.
- Highlighted supporting agents such as Ascorbic acid, Azithromycin, Corticosteroids, Nitric oxide, and IL-6 antagonists.
- Compiled a list of plausible therapeutic options for COVID-19 management.
Conclusions:
- Repurposed drugs show potential for treating COVID-19 patients.
- This review offers an updated resource for managing SARS-CoV-2 infection.
- These therapeutic strategies aim to mitigate COVID-19 impact until definitive treatments are approved.
Keywords:
AnakinraAzithromycinCOVID-19ChloroquineConvalescent plasmaEpoprostenolFavipiravirHydroxychloroquineLopinavirMethylprednisoloneNitric oxideOseltamivirRemdesivirSAR-CoV-2SarilumabSirolimusTocilizumabTraditional Chinese MedicineUmifenovirVitamin CMore Related Videos
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