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Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Glioblastoma multiforme mimicking optic neuritis.

Meera S Ramakrishnan¹, Robin A Vora², Aubrey L Gilbert³

¹Kaiser Permanente Oakland Medical Center, 3600 Broadway, Oakland, CA, 94611, USA.

American Journal of Ophthalmology Case Reports

|May 13, 2020

Summary

This case report details a rare glioblastoma multiforme initially mimicking optic neuritis. Early recognition of potential neoplasms is crucial for adult optic nerve conditions.

Keywords:

Central retinal artery occlusion Central retinal vein occlusion Fourth nerve palsy Glioblastoma multiforme Optic neuritis Third nerve palsy

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Area of Science:

Neuro-oncology
Ophthalmology

Background:

Glioblastoma multiforme (GBM) is an aggressive primary brain tumor.
Optic nerve involvement can present with varied ophthalmic manifestations.

Observation:

A 48-year-old man presented with isolated ophthalmic symptoms suggestive of optic neuritis.
Initial MRI revealed optic nerve abnormalities, treated with steroids.
Rapid visual decline and orbital apex syndrome preceded diagnosis of GBM involving optic nerve, chiasm, and brain structures.

Findings:

The patient was diagnosed with WHO grade IV glioblastoma multiforme.
Tumor progression was rapid, with poor response to temozolomide, bevacizumab, and radiation therapy.
The patient's outcome was poor, with mortality within 5 months.

Implications:

This case underscores the importance of considering neoplasms in the differential diagnosis of adult optic neuritis.
Malignant optic gliomas in adults present diagnostic challenges and have a poor prognosis.
Timely and accurate diagnosis is critical for managing rare presentations of aggressive brain tumors.