Related Experiment Video
Updated: Dec 21, 2025

03:07
Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
Published on: August 19, 2025
650
Breast cancer screening: a dividing controversy
La Tunisie Medicale
|May 13, 2020
Summary
Breast cancer screening reduces mortality by 15-30% but faces controversy due to potential overdiagnosis, which requires clearer definition and estimation.
Area of Science:
- Oncology
- Public Health
- Medical Screening
Background:
- Breast cancer screening is a critical public health intervention.
- The benefits and harms of screening remain a subject of ongoing research and debate worldwide.
- Tunisia's context for breast cancer screening requires specific evaluation.
Purpose of the Study:
- To synthesize conclusions from global and Tunisian literature on breast cancer screening benefits and harms.
- To evaluate the impact of screening modalities like mammography.
- To address the controversy surrounding overdiagnosis in breast cancer detection.
Main Methods:
- Systematic review of 36 articles published between 2001 and 2018.
- Literature search using specialized databases (PubMed, Science Direct).
- Keywords included: Screening, Breast Cancer, Overdiagnosis, Mammography, Controversy, In Situ Tumour.
Main Results:
- Randomized trials estimate breast cancer mortality reduction between 15-30% due to screening.
- Overdiagnosis, a significant concern, is estimated to range from 0-50%.
- Screening has demonstrated utility in cancer control efforts.
Conclusions:
- Breast cancer screening is valuable in combating cancer.
- Screening remains controversial due to overdiagnosis, particularly with advanced therapies.
- Further precise definition and accurate estimation of overdiagnosis are necessary.
Related Concept Videos
Cancer Prevention
7.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.5K
Cancer Vaccines
869
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
869
Cancer-Critical Genes II: Tumor Suppressor Genes
9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K
mTOR Signaling and Cancer Progression
4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.5K
Bias in Epidemiological Studies
1.1K
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
1.1K
Mouse Models of Cancer Study
6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K

