Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angular homeostasis. V: Some issues in genetics, ontogeny, and evolution.

E A Murphy1, K R Berger, J E Trojak

  • 1Division of Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

American Journal of Medical Genetics
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine learning outperforms clinical experts in classification of hip fractures.

Scientific reports·2022
Same author

The multiple effects of aspirin in prostate cancer patients.

Cancer treatment and research communications·2020
Same author

Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota.

Brain, behavior, and immunity·2019
Same author

Biweekly administration of docetaxel and carboplatin for advanced or recurrent endometrial and ovarian carcinomas.

European journal of gynaecological oncology·2018
Same author

Donor site morbidity after vascularized fibula free flap: gait analysis during prolonged walk conditions.

International journal of oral and maxillofacial surgery·2017
Same author

Leptin resistance elicits depressive-like behaviors in rats.

Brain, behavior, and immunity·2016

This study proposes a model for cell growth direction, integrating genetics and development to study congenital defects. It aims to understand how genomes form phenotypes and the evolutionary path of development with minimal mutations.

Area of Science:

  • Developmental Biology
  • Evolutionary Genetics
  • Cell Biology

Background:

  • Understanding normal cell growth and structural organization is crucial for developmental biology.
  • Genetics, ontogeny (development), and phylogeny (evolution) interact complexly in normal development and its defects.

Purpose of the Study:

  • To define a parsimonious model for statistically efficient genetic studies of congenital defects.
  • To address how the genome translates into a clinically observable phenotype for genetic selection and evolution.
  • To explore the evolutionary pathway of ontogenesis with minimal mutations and conserved intermediate stages.

Main Methods:

  • Provisional modeling of cell growth control.
  • Integration of genetic, developmental, and evolutionary principles.

Related Experiment Videos

  • Addressing classical questions in developmental genetics and evolution.

    • Main Results:

    • A framework is proposed for analyzing the genetic basis of congenital defects.
    • The model facilitates understanding genotype-phenotype relationships in an evolutionary context.
    • It provides a heuristic approach to studying developmental pathways.

    Conclusions:

    • The proposed model offers a foundation for genetic studies of congenital defects.
    • It enhances the understanding of evolutionary developmental biology.
    • It addresses fundamental questions regarding phenotype development and evolutionary pathways.