Related Experiment Video
Updated: Dec 21, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
[No scientific lower threshold for compulsory vaccination]
D Klinkenberg1,2, I K Veldhuijzen1, W L M Ruijs1
1Rijksinstituut voor Volksgezondheid en Milieu, Centrum voor Infectieziektebestrijding, Bilthoven.
None:
The national vaccination rate in young children in the Netherlands has decreased in recent years. This has led to social and political discussions, for instance about compulsory vaccination for children in child-care. The national commission on child-care and vaccination has advised that vaccination should be made compulsory when the rate of vaccination has declined to a pre-determined lower threshold, to be determined by the government. A frequently quoted lower threshold is 95%. The idea behind this is the concept of a critical vaccination rate, a threshold needed for elimination of an infection in a large, well-mixed population. In this article we argue why the critical vaccination rate does not offer a scientific basis for a lower threshold to the national vaccination rate.
Related Concept Videos
Vaccinations
Obedience
Bias in Epidemiological Studies
Criteria for Causality: Bradford Hill Criteria - II
Principles of Disease Surveillance
Bioequivalence studies: Biowaivers

