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[Dealing with COVID-19-associated coagulopathy]

Frederikus A Klok1,2, Paul L den Exter1, Menno V Huisman1

  • 1Leids Universitair Medisch Centrum, afd. Trombose en Hemostase, Leiden.

Nederlands Tijdschrift Voor Geneeskunde
|May 13, 2020
PubMed

Insights

Activation of the coagulation cascade, known as COVID-19-associated coagulopathy, is common in patients with COVID-19 and predicts poor outcomes. This review provides essential guidance for managing coagulopathy in Dutch clinical practice.

Area of Science:

  • Internal Medicine
  • Hematology
  • Infectious Diseases

Background:

  • COVID-19 frequently causes activation of the coagulation cascade, termed COVID-19-associated coagulopathy.
  • This coagulopathy is linked to increased mortality and adverse patient outcomes.
  • Current management guidelines are based on limited, often retrospective, data, leading to inconsistencies.

Purpose of the Study:

  • To review early research on COVID-19-associated coagulopathy.
  • To provide practical recommendations for the diagnosis and management of coagulopathy in COVID-19 patients.
  • To outline strategies for preventing complications related to coagulopathy in clinical settings.

Main Methods:

  • Review of published studies on COVID-19-associated coagulopathy.
  • Synthesis of findings to establish clinical best practices.
  • Focus on diagnostics, daily management, and complication prevention.

Main Results:

  • COVID-19-associated coagulopathy is a significant predictor of patient prognosis.
  • Evidence-based recommendations for managing coagulopathy are crucial.
  • Proactive prevention of complications is essential for patient care.

Conclusions:

  • Effective management of COVID-19-associated coagulopathy requires clear diagnostic and therapeutic strategies.
  • This review offers practical guidance for Dutch clinicians.
  • Standardizing care can improve outcomes for patients with COVID-19 and coagulopathy.

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