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IgA nephropathy in patients with familial Mediterranean fever
R Said1, N Nasrallah, Y Hamzah
1Department of Medicine, School of Medicine, Jordan University, Amman.
Abstract:
Two patients with a long-standing history of familial Mediterranean fever were found to have both microscopic hematuria and proteinuria during the acute attacks. Kidney biopsies from both patients revealed diffuse mesangial proliferative glomerulonephritis with intense mesangial IgA and C3 deposits and no evidence of amyloidosis. To our knowledge these are the first 2 cases documenting the presence of mesangial IgA nephropathy in patients with familial Mediterranean fever.
Insights
Familial Mediterranean Fever patients can develop IgA nephropathy, a kidney disease. This study documents two such cases, highlighting a previously unrecognized association.
Area of Science:
- Nephrology
- Immunology
- Genetics
Background:
- Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder.
- FMF typically presents with recurrent episodes of fever and serositis.
- Kidney involvement in FMF is usually associated with amyloidosis.