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Nutraceuticals and Metastasis Development
Lara Saftić Martinović1, Željka Peršurić1, Krešimir Pavelić2
1University of Rijeka, Department of Biotechnology, Radmile Matejčić 2, HR-51000 Rijeka, Croatia.
Molecules (Basel, Switzerland)
|May 14, 2020
Summary
Nutrigenomics explores how diet affects genes. This review examines how nutraceuticals impact cancer metastasis, a key cause of cancer death, highlighting both potential benefits and risks.
Area of Science:
- Nutrigenomics and molecular oncology.
- Investigating dietary impacts on gene expression and cellular pathways.
- Focus on
Background:
- Nutrigenomics investigates dietary components' effects on gene expression.
- Anticancer properties of nutraceuticals are widely studied.
- Cancer metastasis causes approximately 90% of cancer-related deaths.
Purpose of the Study:
- To review recent findings on nutraceuticals' effects on cancer metastasis.
- To address the under-explored area of nutraceuticals and metastasis.
- To synthesize knowledge on how dietary compounds influence metastatic spread.
Main Methods:
- Literature review of studies published in the past five years.
- Analysis of research on nutraceuticals and their molecular mechanisms.
- Synthesis of data on metastasis promotion or inhibition by dietary compounds.
Main Results:
- Some nutraceuticals may promote metastasis development.
- Certain compounds can reduce primary tumors but enhance metastasis.
- Limited research exists on nutraceuticals' specific effects on metastasis.
Conclusions:
- The impact of nutraceuticals on cancer metastasis requires further investigation.
- Understanding these effects is crucial given metastasis's role in cancer mortality.
- Future research should focus on discerning dual effects of nutraceuticals on primary tumors and metastasis.
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