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SERS-Based Biosensors for Virus Determination with Oligonucleotides as Recognition Elements.

Oganes Ambartsumyan1, Dmitry Gribanyov2, Vladimir Kukushkin2

  • 1Mechnikov Research Institute of Vaccines and Sera, Moscow 105064, Russia.

International Journal of Molecular Sciences
|May 14, 2020
PubMed
Summary

Rapid viral pathogen identification is crucial. Surface-enhanced Raman spectroscopy (SERS) biosensors using oligonucleotide recognition elements offer a sensitive and specific diagnostic solution for viral infections.

Keywords:
SERSaptamerbiosensorsnanoparticlenucleic acidsoligonucleotidevirus

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Area of Science:

  • Biomedical Engineering
  • Spectroscopy
  • Nanotechnology

Background:

  • Viral infections pose significant global health risks, necessitating accurate and rapid diagnostic tools.
  • Current diagnostic methods often lack the required speed, sensitivity, or specificity for timely pathogen identification.
  • Surface-enhanced Raman spectroscopy (SERS) presents a promising label-free technique for sensitive biomolecular detection.

Purpose of the Study:

  • To review the application of SERS-based biosensors for viral pathogen identification.
  • To discuss the potential of using oligonucleotides as recognition elements in SERS biosensors.
  • To highlight the advantages of SERS for routine viral diagnostics.

Main Methods:

  • Review of existing literature on SERS biosensors for virus detection.
  • Focus on biosensors utilizing oligonucleotides as specific recognition elements.
  • Analysis of SERS principles, nanostructure requirements, and recognition element strategies.

Main Results:

  • SERS demonstrates exceptional sensitivity due to nanostructure amplification.
  • Specificity can be achieved through the integration of recognition elements like oligonucleotides.
  • Oligonucleotide-based SERS biosensors show significant potential for accurate virus identification.

Conclusions:

  • SERS-based biosensors are a viable and promising technology for rapid viral diagnostics.
  • Oligonucleotides offer a specific and effective recognition mechanism for virus detection via SERS.
  • Further development of SERS biosensors could revolutionize routine viral pathogen identification.