Related Experiment Video
Updated: Dec 21, 2025
06:08
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
2.2K
Primary thyroid squamous cell carcinoma - a Scottish National Case Series
Alison E Lim1, Paul Sooby2, Richard B Townsley3
1Foundation Doctor, Department of Otolaryngology, Head and Neck Surgery, Crosshouse University Hospital, Kilmarnock, NHS Ayrshire and Arran, UK.
Scottish Medical Journal
|May 14, 2020
Summary
This case series on primary thyroid squamous cell carcinoma (PTSCC) found unexpectedly good outcomes in three patients, suggesting a potential subgroup with better survival rates for this aggressive cancer.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Primary thyroid squamous cell carcinoma (PTSCC) is a rare and aggressive malignancy.
- The prognosis for PTSCC is classically poor, with rapid progression and low survival rates.
Observation:
- A national case series identified three patients diagnosed with PTSCC over a 10-year period.
- All three patients underwent surgical resection, with two receiving adjuvant chemoradiotherapy.
- One patient received nivolumab, while another received standard chemoradiotherapy.
Findings:
- Two of the three patients remain disease-free over two years post-diagnosis, demonstrating an unusually favorable outcome.
- One patient experienced disease progression and died 10 months post-diagnosis.
- The observed survival in two patients contrasts with the typically aggressive nature and poor prognosis of PTSCC.
Implications:
- The findings suggest the possibility of a distinct subgroup of PTSCC patients with a more indolent disease course and better survival.
- Further research is warranted to identify prognostic markers and understand the biological basis for varied outcomes in PTSCC.
- A tailored, patient-centered management approach may optimize treatment strategies and improve outcomes for individuals with PTSCC.
