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Updated: Dec 21, 2025
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
Primary thyroid squamous cell carcinoma - a Scottish National Case Series
Alison E Lim1, Paul Sooby2, Richard B Townsley3
1Foundation Doctor, Department of Otolaryngology, Head and Neck Surgery, Crosshouse University Hospital, Kilmarnock, NHS Ayrshire and Arran, UK.
Aim:
To present our national case series on primary thyroid squamous cell carcinoma (PTSCC) and add to the current literature about this rare and aggressive disease.
Methods:
Scottish pathology departments were contacted and asked to provide details of patients with the diagnosis of PTSCC from the last 10 years. Three patients were included.
Results:
Patients 1, 2 and 3 underwent surgical resection. Patients 1 and 3 went on to receive chemoradiotherapy. Patient 1 received nivolumab. Patient 1 died 10 months following diagnosis. Patient 2 and 3 are currently living with no recurrence, over two years post-diagnosis.
Conclusion:
This case series has demonstrated an unusually good set of outcomes for a classically rapidly progressing disease with poor survival rates. This raises the question whether there is a subgroup of PTSCC associated with better outcomes and lower mortality. A patient-centred approach will give optimal patient management.
