Inflammation, diet, and type 2 diabetes: a mini-review
Simin Jafaripour1, Sima Sedighi2, Mohammad Hassan Jokar2
1Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran.
Journal of Immunoassay & Immunochemistry
|May 14, 2020
Summary
Inflammation, marked by increased cytokines like CRP and TNF-α, is linked to type 2 diabetes. Diet
Area of Science:
- Biomedical Science
- Immunology
- Metabolic Disorders
Background:
- Inflammation is a key characteristic of type 2 diabetes (T2D).
- Elevated inflammatory cytokines are observed in T2D, metabolic syndrome, and heart disease.
- Cytokines produced by various cells trigger tissue-specific immune responses via bloodstream interactions.
Purpose of the Study:
- To review the role of specific inflammatory markers in T2D.
- To focus on C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and adiponectin.
- To highlight the need for research on dietary macronutrient effects on these cytokines.
Main Methods:
- Literature review focusing on inflammatory cytokines in T2D.
- Analysis of studies examining CRP, TNF-α, and adiponectin.
- Synthesis of current knowledge regarding cytokine involvement in T2D pathogenesis.
Main Results:
- C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) are significant inflammatory cytokines.
- Adiponectin, produced by adipose tissue, also plays a role.
- These cytokines are implicated in the development and progression of T2D.
Conclusions:
- Inflammatory cytokines are crucial in T2D development.
- Further research is needed to understand how dietary macronutrient composition influences these cytokines.
- Investigating diet's impact may reveal new therapeutic strategies for T2D.
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