Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mechanisms of Macrophage Immunomodulatory Activity Induced by a New Polysaccharide Isolated From <i>Polyporus umbellatus</i> (Pers.) Fries.

Frontiers in chemistry·2020

Same author

Relationships Between Vasomotor Symptoms and Mood in Midlife Urban Chinese Women: Observations in a Prospective Study.

The Journal of clinical endocrinology and metabolism·2020

Same author

Background and fingerprint characteristics of anthropogenic <sup>236</sup>U and<sup>137</sup>Cs in soil and road dust samples collected from Beijing and Zhangjiakou, China.

Chemosphere·2020

Same author

Bedaquiline inhibits the yeast and human mitochondrial ATP synthases.

Communications biology·2020

Same author

From centrosymmetric to noncentrosymmetric: intriguing structure evolution in d<sup>10</sup>-transition metal iodate fluorides.

Chemical communications (Cambridge, England)·2020

Same author

Effects of Microwave-Assisted Extraction Conditions on Antioxidant Capacity of Sweet Tea (<i>Lithocarpus polystachyus</i> Rehd.).

Antioxidants (Basel, Switzerland)·2020

Search research articles

Related Experiment Video

Updated: Dec 21, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Nanoengineered targeting strategy for cancer immunotherapy.

Wei-Min Yin¹, Yu-Wei Li¹, Yun-Qing Gu¹

¹Institute of Pediatrics, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.

Acta Pharmacologica Sinica

|May 14, 2020

Summary

Cancer immunotherapy harnesses the immune system to fight tumors. Nanotechnology offers novel nanoengineered vaccines and nanomedicine strategies to enhance T cell responses and overcome tumor immunosuppression for improved cancer treatment.

Keywords:

cancer immunotherapy cancer vaccine immune resistance immunosuppressive microenvironment nanomedicine nanovaccine

More Related Videos

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

Related Experiment Videos

Last Updated: Dec 21, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

Area of Science:

Oncology
Immunology
Nanotechnology
Biomedical Engineering

Background:

Cancer immunotherapy, particularly checkpoint inhibitors, shows promise but benefits only a subset of patients.
Limitations include insufficient T cell responses, low tumor immunogenicity, and a suppressive tumor microenvironment.
Nanotechnology presents a unique approach to address these challenges in cancer treatment.

Purpose of the Study:

To review how nanoengineered vaccines can stimulate potent T cell responses against tumors.
To explore how nanomedicine can modify the tumor microenvironment to enhance antitumor immunity.
To highlight advancements in nanotechnology for cancer immunotherapy.

Main Methods:

Review of current research on nanotechnology applications in cancer immunotherapy.
Analysis of nanoengineered vaccine strategies for T cell activation.
Examination of nanomedicine approaches for modulating the tumor microenvironment.

Main Results:

Nanoengineered vaccines demonstrate potential for inducing robust T cell-mediated antitumor immunity.
Nanomedicine can effectively remodel the immunosuppressive tumor microenvironment, boosting immune responses.
Integration of nanotechnology offers multifaceted strategies to improve immunotherapy efficacy.

Conclusions:

Nanotechnology provides innovative platforms for developing next-generation cancer immunotherapies.
Nanoengineered vaccines and nanomedicine hold significant promise for overcoming current immunotherapy limitations.
Further research in nanomedicine is crucial for advancing cancer treatment paradigms.