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Updated: Dec 21, 2025
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Prospective evaluation of risk-appropriate management of uveal melanoma patients informed by gene expression
Amy C Schefler1, Alison Skalet2, Scott Cn Oliver3
1Retina Consultants of Houston, Houston, TX 77030, USA.
Aim:
The Clinical Application of DecisionDx-UM Gene Expression Assay Results study aimed to evaluate the clinical utility of the prognostic 15-gene expression profile (15-GEP) test for uveal melanoma (UM) patients in a large, prospective multicenter cohort.
Patients & Methods:
Nine centers prospectively enrolled 138 UM patients clinically tested with the 15-GEP. Physician-recommended specialty referrals and metastatic surveillance regimens were collected.
Results:
A total of 93% of high-risk class 2 patients were referred to medical oncology for follow-up, compared with 51% of class 1 patients. A majority (62%) of class 2 patients were recommended overall high-intensity metastatic surveillance, while 85% of class 1 patients were recommended low-intensity metastatic surveillance.
Conclusion:
Treatment plan recommendations for UM patients are aligned with GEP-informed metastatic risk, consistent with prior studies.
