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Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
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Resolution of experimental microvascular vasoconstriction in rats by topical application of lidocaine hydrochloride

W H Beekman1, J E Sluimers, W J Kort

  • 1Department of Plastic and Reconstructive Surgery, Academic Hospital Dijkzigt, Rotterdam, the Netherlands.

Annals of Plastic Surgery
|December 1, 1988
PubMed

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Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...