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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
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Human toxocariasis and atopy.

Jean-François Magnaval1, Judith Fillaux2, Sophie Cassaing2

  • 1Service de Parasitologie Médicale, Faculté de Médecine, Université de Toulouse, 31000 Toulouse, France.

Parasite (Paris, France)
|May 14, 2020
PubMed
Summary
This summary is machine-generated.

Atopy, a predisposition to allergic diseases, does not alter the clinical presentation or laboratory findings in human toxocariasis patients. This study found no significant impact of allergic status on toxocariasis disease presentation.

Keywords:
AtopyClinical pictureEosinophiliaHuman toxocariasisIgEOutcome

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Area of Science:

  • Medical Parasitology
  • Clinical Immunology
  • Epidemiology

Background:

  • Human toxocariasis is a parasitic infection with a variable clinical spectrum.
  • Atopy, characterized by a genetic predisposition to allergic diseases, is common in the general population.
  • The potential interaction between atopy and the clinical manifestation of toxocariasis remains underexplored.

Purpose of the Study:

  • To investigate whether atopic status influences the clinical and laboratory features of human toxocariasis.
  • To compare the presentation of toxocariasis in patients with and without atopy.

Main Methods:

  • A retrospective study analyzed 106 patient records with diagnosed toxocariasis.
  • Patients were classified as atopic (allergic history, high specific IgE) or non-atopic (negative specific IgE).
  • Demographic, clinical (20 signs/symptoms), and laboratory variables (eosinophils, IgE levels) were analyzed using bivariate and multivariate regression.

Main Results:

  • No significant differences were observed in the clinical signs or symptoms of toxocariasis between atopic and non-atopic groups.
  • Laboratory parameters, including blood eosinophil count, eosinophil cationic protein, and total/specific IgE levels, did not differ significantly between the two groups.
  • Multivariate analysis confirmed that atopic status did not predict any specific clinical or laboratory outcome in toxocariasis.

Conclusions:

  • The presence of atopy does not appear to modify the clinical or laboratory presentation of human toxocariasis.
  • Further research may be needed to explore other potential factors influencing toxocariasis disease severity or presentation.