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Revenant: a database of resurrected proteins.

Matias Sebastian Carletti1, Alexander Miguel Monzon1,2, Emilio Garcia-Rios3

  • 1Departamento de Ciencia y Tecnología, CONICET, Universidad Nacional de Quilmes, Roque Saenz Peña 182, Bernal, B1876BXD, Buenos Aires, Argentina.

Database : the Journal of Biological Databases and Curation
|May 14, 2020
PubMed
Summary

Revenant is a database of 84 resurrected proteins from extinct organisms, aiding evolutionary research. This resource provides structural and biochemical data for ancient proteins, enabling new scientific insights.

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Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Bioinformatics

Background:

  • Resurrected proteins offer insights into evolutionary history.
  • Databases are crucial for organizing and accessing such specialized data.

Purpose of the Study:

  • To present Revenant, a curated database of resurrected proteins.
  • To facilitate research on ancient protein functions and evolution.

Main Methods:

  • Manual curation of bibliographic data for protein information.
  • Ancestral sequence reconstruction (computational) combined with wet-lab synthesis and expression.
  • Database development with timeline browsing and detailed annotation.

Main Results:

  • Revenant contains 84 manually curated resurrected proteins.
  • Proteins range from 4200 to 3500 million years ago and 8.8 to 6.3 million years ago.
  • Each entry includes structural, biochemical, and biophysical data.

Conclusions:

  • Revenant serves as a valuable resource for studying ancient proteins.
  • The database supports research into protein stability, function origins, and ancient metabolisms.