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Key Genes Associated with Prognosis and Tumor Infiltrating Immune Cells in Gastric Cancer Patients Identified by
Tao Zhang1,2, Bo-Fang Wang1, Xue-Yan Wang1
1The Second Clinical Medical College of Lanzhou University, Lanzhou, China.
Cancer Biotherapy & Radiopharmaceuticals
|May 14, 2020
Summary
This study identifies six key genes (hub genes) linked to gastric cancer (GC) progression and patient prognosis. These genes also correlate with immune cell infiltration, offering potential therapeutic targets for GC.
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- The molecular mechanisms driving gastric cancer (GC) progression remain incompletely understood.
- Identifying key genes and their roles in GC is crucial for developing effective therapeutic strategies.
Purpose of the Study:
- To investigate the molecular mechanisms of gastric cancer (GC) progression.
- To identify key genes associated with GC prognosis and tumor-infiltrating immune cells.
Main Methods:
- Utilized Gene Expression Omnibus (GEO) datasets to identify differentially expressed genes (DEGs) in GC.
- Performed enrichment analysis for DEGs and constructed protein-protein interaction networks.
- Analyzed hub genes, their expression, prognostic value, and correlation with tumor-infiltrating immune cells using Tumor IMmune Estimation Resource.
Main Results:
- Identified 265 differentially expressed genes (DEGs) across six GEO datasets.
- Six hub genes (TOP2A, FN1, SPARC, COL3A1, COL1A1, TIMP1) were significantly associated with GC molecular mechanisms and prognosis.
- Five hub genes showed a positive correlation with macrophages, neutrophils, and dendritic cells.
Conclusions:
- The identified hub genes may serve as potential prognostic markers for gastric cancer.
- These findings provide a theoretical foundation for understanding GC molecular regulation and developing novel therapeutic targets.
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