Chronic stress and anticipatory event-related potentials: the moderating role of resilience

Chronic stress exposure is associated with impaired cognitive function; however, the underlying mechanism is not yet clear. This study investigated the association between perceived chronic stress and anticipatory processing, measured by event-related potentials, and the moderating role of resilience on this relationship in healthy adults. Fifty-nine healthy volunteers (22.52 ± 1.75 years) underwent a continuous performance test, and anticipatory processing was indexed with the contingent negative variation (CNV) of event-related potentials, the Cohen Perceived Stress Scale, and the Connor-Davidson Resilience Scale. The results showed that greater reports of perceived chronic stress were associated with more negative early CNVs; however, there was no significant relationship between perceived chronic stress and behavioral performance on the continuous performance test. More importantly, the relationship between perceived chronic stress and early CNV was moderated by resilience as the association between the Cohen Perceived Stress Scale score and early CNV amplitude was significant for low and average levels of resilience. These results not only suggest that chronic stress may lead to decreased cognitive efficiency in cortical anticipatory activity, but also underscore the role of resilience as a key protective factor in decreased cognitive efficiency.