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Tissue engineering applications in breast cancer.

Mozaffar Mahmoodi^1,2, Shirin Ferdowsi³, Somayeh Ebrahimi-Barough¹

¹Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Medical Engineering & Technology

|May 14, 2020

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Tissue engineering (TE) offers innovative breast cancer (BC) treatments and models tumor microenvironments for drug testing. This review highlights advancements in breast TE and Iranian research contributions.

Area of Science:

Biomedical Engineering
Oncology
Regenerative Medicine

Background:

Breast cancer (BC) is the most common cancer in Iranian women, typically treated with surgery, chemotherapy, and radiation.
Tissue engineering (TE) presents novel therapeutic strategies for tissue loss in BC patients by developing functional tissue substitutes.
Integrating cancer biology with TE offers a new avenue for evaluating anti-BC therapies.

Purpose of the Study:

To review recent advancements in the application of tissue engineering (TE) for breast cancer (BC).
To highlight the contributions of Iranian researchers in the field of breast TE.
To discuss the development of engineered 3D cultures for modeling the tumor microenvironment and drug efficacy studies.

Main Methods:

Review of recent literature on tissue engineering in breast cancer.

Keywords:

Tissue engineering application breast cancer

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Analysis of innovations in scaffold/matrix-based culture systems mimicking the extracellular matrix (ECM).

Examination of engineered three-dimensional (3D) cultures for tumor microenvironment modeling.

Main Results:

Tissue engineering innovations have led to scaffold systems that better mimic the native ECM.
Engineered 3D cultures are increasingly used to model the tumor microenvironment.
These 3D models facilitate accurate in vitro studies of molecular mechanisms and drug effects.

Conclusions:

Tissue engineering provides promising approaches for breast cancer treatment and research.
The development of 3D engineered cultures enhances in vitro modeling for drug evaluation.
Iranian researchers have made notable achievements in breast tissue engineering.