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Related Concept Videos

Drug Product Stability01:16

Drug Product Stability

120
The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
137
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

101
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
101
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

419
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
419

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Quality Control: Photostability of Compounded Preparations.

Loyd V Allen1

  • 1International Journal of Pharmaceutical Compounding. lallen@ijpc.com.

International Journal of Pharmaceutical Compounding
|May 14, 2020
PubMed
Summary

Light exposure can degrade medications, necessitating protective packaging for approximately 25% of drugs. Proper handling and storage are crucial to maintain drug stability and efficacy, especially for light-sensitive compounds.

Area of Science:

  • Pharmaceutical Science
  • Drug Stability
  • Packaging Technology

Background:

  • Drug stability is influenced by environmental factors like light, moisture, oxygen, and temperature.
  • A significant portion of marketed drugs (around 25%) require light-resistant packaging.
  • The rate of drug degradation due to light sensitivity varies considerably across different drug classes.

Purpose of the Study:

  • To highlight the importance of light protection in maintaining drug stability.
  • To inform about the necessity of light-resistant packaging for a substantial number of pharmaceutical products.
  • To emphasize the role of environmental controls and packaging in preventing drug degradation.

Main Methods:

  • Review of factors affecting drug stability.

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  • Analysis of the prevalence of light-sensitive drugs in the market.
  • Discussion of compounding and storage best practices for light-sensitive medications.

    • Main Results:

    • Approximately 25% of drugs require light-resistant packaging.
    • Environmental controls and minimized light exposure are essential during compounding.
    • Proper packaging, storage, and distribution are critical for preserving drug integrity.

    Conclusions:

    • Light sensitivity is a key factor in drug stability, impacting a quarter of all drugs.
    • Pharmacists must be aware of drug-specific light protection needs.
    • Comprehensive strategies, from compounding to patient administration, are vital for light-sensitive drugs.