Sterile Basics: Intravenous Admixture Preparation Considerations, Part 4: Particulates
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1International Journal of Pharmaceutical Compounding. lallen@ijpc.com.
Abstract:
Intravenous admixture compounding requires knowledge of stability, compatibility, and incompatibility issues related to the complete composition and formulation. In evaluating an intravenous admixture, one is not just concerned with the active ingredients but also with all the excipients. Both active pharmaceutical ingredients and excipients used in the formulations of commercially available products may vary among manufacturers and can influence drug compatibility and stability. Clinical pharmaceutics includes the study and application of pharmaceutics to clinical compounding situations to aid in the evaluation of each intravenous admixture. A critical aspect of successful intravenous admixture preparation is the prevention or minimization of particulate matter in the finished product. This article discusses the source, method of prevention, and detection of particulates in intravenous admixtures.
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