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Updated: Dec 21, 2025

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
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Newborn body composition after maternal bariatric surgery.

Emma Malchau Carlsen1, Kristina Martha Renault2,3, Bertha Kanijo Møller1

  • 1Department of Pediatrics, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Plos One
|May 14, 2020
PubMed
Summary

Pregnancy after Roux-en-Y gastric bypass (RYGB) surgery impacts offspring body composition. Babies born after RYGB had lower birthweight, fat-free mass, and fat percentage, with surgery itself being the primary factor, not pre-pregnancy weight loss.

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Area of Science:

  • Reproductive Medicine
  • Pediatric Endocrinology
  • Bariatric Surgery Outcomes

Background:

  • Pregnancy following Roux-en-Y gastric bypass (RYGB) is associated with an increased risk of low birthweight in offspring.
  • Understanding the impact of RYGB on neonatal body composition is crucial for optimizing maternal and infant health outcomes.

Purpose of the Study:

  • To investigate the effects of RYGB on the body composition of newborns.
  • To differentiate the impact of maternal pre-pregnancy weight loss versus other surgical effects on fetal growth.

Main Methods:

  • A cohort study comparing 25 mother-newborn dyads post-RYGB with 311 control dyads.
  • Neonatal body composition assessed via dual-energy X-ray absorptiometry (DXA) within 48 hours of birth.
  • Statistical models analyzed the influence of maternal pre-pregnancy BMI, gestational weight gain, parity, gestational age, and newborn sex.

Main Results:

  • Offspring born after RYGB exhibited significantly lower birthweight (335g), fat-free mass (268g), and fat percentage (2.8%) compared to controls.
  • Maternal pre-pregnancy weight loss accounted for only 2% of the reduction in neonatal fat-free mass.
  • RYGB surgical effects, rather than weight loss, were responsible for 98% of the fat-free mass reduction and 47% of the fat mass reduction.

Conclusions:

  • Neonatal body composition, including birthweight, fat-free mass, and fat percentage, is reduced in offspring born after maternal RYGB.
  • The RYGB procedure itself, independent of pre-pregnancy weight loss, appears to be the primary determinant of altered fetal growth patterns.