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Updated: Dec 21, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Activation of Phospholipase C β by Gβγ and Gαq Involves C-Terminal Rearrangement to Release Autoinhibition

Isaac J Fisher1, Meredith L Jenkins2, Gregory G Tall3

  • 1Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14629, USA.

Structure (London, England : 1993)
|May 14, 2020
PubMed

Keywords:
G proteinG-protein-coupled receptorGPCRGαqGβγHDX-MShydrogen-deuterium exchangelipidsmembrane interactionsphospholipase Cprotein dynamicssignal transduction

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