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Association between mitochondrial DNA haplogroup variation and coronary artery disease

Fangyi Xiao1, Meinan Li2, Junyi Wang2

  • 1Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|May 14, 2020
PubMed

Insights

Mitochondrial DNA (mtDNA) haplogroups are not linked to coronary artery disease (CAD) in Chinese populations. Environmental factors and nuclear genes likely play a more significant role in CAD development.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research

Background:

  • Mitochondrial DNA (mtDNA) haplogroups are implicated in coronary artery disease (CAD) in Europeans.
  • The association between mtDNA haplogroups and CAD in Chinese populations remains uninvestigated.

Purpose of the Study:

  • To investigate the association between mtDNA haplogroups and CAD in southern and northern Chinese populations.
  • To examine the relationship between mtDNA haplogroups and CAD severity, acute coronary syndromes, stable coronary heart disease, type 2 diabetes, and hypertension.

Main Methods:

  • A case-control study was conducted with 1036 CAD patients and 973 controls in southern China, and 481 CAD patients and 511 controls in northern China.
  • Mitochondrial DNA haplogroup frequencies were analyzed and adjusted for age and gender.

Main Results:

  • Mitochondrial DNA haplogroups were not associated with the occurrence of CAD or its subcategories in either southern or northern Chinese populations.
  • No association was found between mtDNA haplogroups and CAD severity in the southern Chinese population.
  • Frequencies of 12 studied mtDNA haplogroups did not differ between patients with and without type 2 diabetes or hypertension.

Conclusions:

  • Mitochondrial DNA haplogroups are not associated with coronary artery disease occurrence or subcategories in Chinese populations.
  • Environmental factors and nuclear genetic background may be more significant contributors to CAD in Chinese populations.
Abstract

Keywords:
Acute coronary syndromeChinese populationCoronary artery diseaseMitochondrial DNA (mtDNA) haplogroupStable coronary heart disease

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