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Acute bromopride treatments: effects on general activity and inhibitory avoidance in rats
1Departamento de Ciências Fisiológicas, Faculdade de Ciências Médicas da Santa Casa, São Paulo, Brasil.
Abstract:
Bromopride (BRO), a dopamine D2 blocker used in gastroenterology clinics, was tested acutely in rats for effects on general activity, measured in an open-field test, and on inhibitory avoidance behavior. Rats that received 2.5 and 5.0 mg/kg BRO showed lower locomotion and rearing frequencies than controls, and 5.0 mg/kg BRO blocked the inhibitory avoidance response. The data suggest that BRO may have neuroleptic effects.