[Bile acids in arrhythmia]
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Updated: Dec 21, 2025

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
Published on: July 3, 2013
1Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Abstract:
With the research advances on bile acid, it has gradually been discovered and confirmed that high levels of bile acids can cause various types of arrhythmias, such as sinus bradycardia, atrial fibrillation (AF), atrioventricular block and even occurrence of cardiac arrest in severe cases. In addition, it has also been found that fetuses are more susceptible to bile acid-induced arrhythmias than adults. It has been recognized that bile acids can cause arrhythmias through a variety of mechanisms, such as the effect of bile acids on ions and ion channels, receptor-mediated, vagal-mediated, and other pathways. Ursodeoxycholic acid (UDCA) is currently found to have protective effect on the heart and has an antiarrhythmic effect. This article mainly reviews the function and mechanism of bile acid in arrhythmia.
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