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Behcet's disease and pregnancy: a systematic review
Lucia Merlino1, Federica Del Prete2, Benedetta Lobozzo1
1Department of Maternal and Child Health and Urological Sciences, Umberto I Polyclinic, Sapienza University, Rome, Italy.
Minerva Ginecologica
|May 15, 2020
Summary
Pregnancy in Behcet's disease (BD) patients is generally safe, potentially improving disease course. Careful monitoring is crucial to manage risks for both mother and child.
Area of Science:
- Rheumatology
- Obstetrics
- Immunology
Background:
- Behcet's disease (BD) is a rare, multisystemic autoimmune disorder.
- Characterized by oral/genital ulcers and eye inflammation, BD can involve thrombotic complications.
- It predominantly affects women of childbearing age, necessitating pregnancy risk assessment.
Purpose of the Study:
- To review literature on pregnancy outcomes in Behcet's disease patients.
- To identify risks to mother and fetus during pregnancy and postpartum.
- To guide appropriate pregnancy management strategies for BD patients.
Main Methods:
- Literature review of existing studies.
- Analysis of consequences of pregnancy on BD course.
- Evaluation of pregnancy-related risks and outcomes in BD.
Main Results:
- Conflicting reports exist on pregnancy's effect on BD activity; some suggest improvement, others worsening.
- Thromboembolic events are a significant concern during pregnancy and postpartum.
- Higher incidence of abortion, intrauterine growth restriction, and C-sections observed in BD patients.
Conclusions:
- Pregnancy is not contraindicated in Behcet's disease patients.
- Pregnancy may improve the course of the disease in many cases.
- Close pregnancy surveillance is essential to mitigate maternal and fetal risks.
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