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Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang

Huiqun Shuai1, Qiao Bian2, Yun Luo3,4

  • 1Xiacheng District Center for Disease Control and Prevention, Hangzhou, China.

BMC Infectious Diseases
|May 15, 2020
PubMed

Insights

Clostridium difficile infection (CDI) is a significant cause of acute gastroenteritis in Chinese children, with diverse C. difficile genotypes identified. Surveillance for toxigenic C. difficile and its risk factors is crucial for pediatric diarrhea management in China.

Area of Science:

  • Microbiology
  • Pediatrics
  • Infectious Diseases

Background:

  • Pediatric Clostridium difficile infection (CDI) prevalence is rising globally.
  • Molecular data on C. difficile in Chinese children with acute gastroenteritis remain limited.

Purpose of the Study:

  • To investigate the molecular characteristics of C. difficile isolates from children with acute gastroenteritis in China.
  • To determine the prevalence and genotypes of C. difficile and associated antimicrobial resistance patterns.

Main Methods:

  • A five-year cross-sectional study analyzed stool specimens from pediatric outpatients.
  • C. difficile isolates were characterized for toxin genes, multi-locus sequence types, and antimicrobial resistance.
  • Diarrhea-related viruses and demographic data were also collected.

Main Results:

  • 115 CDI cases (14.3%) were identified among 804 stool samples.
  • Major C. difficile genotypes included STs 26, 35, 39, 54, and 152.
  • A-B+ isolates showed higher antimicrobial resistance than A+B+ isolates; infants had a higher CDI rate.

Conclusions:

  • CDI is a major cause of acute gastroenteritis in Chinese children, associated with various C. difficile genotypes.
  • Toxigenic C. difficile and specific risk factors warrant consideration in pediatric diarrhea surveillance in China.
Abstract

Keywords:
Acute gastroenteritisChildrenClostridium difficileMolecular characteristics

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