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Risk factors of malnutrition in Chinese children with congenital heart defect
Mingjie Zhang1, Liping Wang1, Rui Huang1
1Cardiac Intensive Care Unit, Department of Thoracic and Cardiovascular Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai, 200127, China.
Insights
Malnutrition significantly impacts children with congenital heart defects (CHD) in China, particularly before surgery. Enhanced nutritional support is crucial, as factors like hospitalization and pulmonary hypertension are linked to preoperative malnutrition.
Area of Science:
- Pediatric Cardiology
- Nutritional Science
- Public Health
Background:
- Malnutrition is a significant concern for children with congenital heart defects (CHD).
- Prevalence and risk factors for malnutrition in this population in China require further investigation.
Purpose of the Study:
- To investigate the risk factors associated with malnutrition in children with CHD in China.
- To assess the impact of surgical intervention and postoperative factors on nutritional status.
Main Methods:
- A cohort study included 3252 pediatric patients with CHD undergoing cardiac surgery.
- Nutritional status was assessed using weight-for-age Z-score (WAZ), weight-for-height Z-score (WHZ), and height-for-age Z-score (HAZ).
- Logistic regression analysis identified factors associated with preoperative and postoperative malnutrition.
Main Results:
- Preoperative malnutrition prevalence: 23.3% underweight, 23.3% stunting, 14.3% wasting.
- Preoperative malnutrition linked to hospitalization, age at surgery, surgical risk, mechanical ventilation, pulmonary hypertension, and heart defect type.
- Postoperative malnutrition associated with residual cardiac abnormalities, heart function classification, and diuretic use.
Conclusions:
- Malnutrition remains a challenge for pediatric CHD patients in China, especially preoperatively.
- Strengthening preoperative nutritional support is essential.
- Hemodynamic factors are key risk factors for malnutrition after surgery.
Background:
The study aimed to investigate the risk factors of malnutrition in children with congenital heart defect (CHD) in China.
Methods:
This cohort study was performed at the biggest pediatric heart center in China; 3252 patients with CHD who underwent cardiac surgeries in 2013 were included. Anthropometric measurements included weight for age Z score (WAZ), weight for height Z score (WHZ), and height for age Z score (HAZ). The patients were classified as normal nutritional status and malnutrition, based on a cut-off Z score of <- 2. Factors associated with malnutrition were determined using logistic regression analysis.
Results:
The prevalence of preoperative WAZ < -2 (underweight), HAZ < -2 (stunting), and WHZ < -2 (wasting) was 23.3, 23.3, and 14.3%, respectively. The multivariable analysis of preoperative malnutrition showed that hospitalization, age at surgery, risk adjustment for congenital heart surgery-1 > 3, mechanical ventilation, pulmonary hypertension, and acyanotic heart disease were associated with underweight. Parents' height, single ventricle, and cyanotic heart disease were associated with stunting. Hospitalization and pulmonary hypertension were associated with wasting. After surgery, the patients presented a significant improvement in growth within the first year in all three parameters and grew to the normal range of WAZ (- 0.3 ± 0.9, P < 0.001), HAZ (0.2 ± 0.8, P = 0.001), and WHZ (0.03 ± 0.6, P < 0.001) at 2 years after surgery. The prevalence of underweight, stunted, and wasting declined to 3.2, 2.7, and 1.9% 3 years after surgery. Malnutrition after surgery was associated with cardiac residual cardiac abnormalities (OR = 35.3, p < 0.0001), high Ross classification of heart function (OR = 27.1, p < 0.0001), and long-term taking oral diuretics (OR = 20.5, P = 0.001).
Conclusions:
Malnutrition is still a problem in children with CHD in China, especially before the surgery. There is need to strengthen the nutrition support for children with CHD before surgery. Hemodynamic factors were found to be the risk factors associated with malnutrition after operation.
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