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Updated: Dec 21, 2025

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
Published on: December 27, 2010
Cohort profile: the STOP HIV/AIDS Program Evaluation (SHAPE) study in British Columbia, Canada
Andrea Bever1, Kate Salters2,3, Clara Tam1
1British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
The Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) Program Evaluation (SHAPE) study shows high HIV treatment success. However, disparities in care persist for marginalized groups, requiring targeted interventions.
Area of Science:
- Public Health
- Epidemiology
- Health Services Research
Background:
- The Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) Program Evaluation (SHAPE) study monitors an HIV testing and treatment expansion program in British Columbia.
- It investigates how sociostructural factors like gender, age, sexual identity, geography, income, and ethnicity affect engagement in HIV care.
Purpose of the Study:
- To monitor the progress of an HIV testing and treatment expansion program.
- To examine how sociostructural determinants influence engagement in HIV care.
- To identify barriers and facilitators for equitable access to HIV treatment and care.
Main Methods:
- A longitudinal cohort study involving 644 British Columbia residents diagnosed with HIV, aged 19 and older.
- Baseline survey data collected between January 2016 and September 2018.
- Ongoing clinical follow-up with two additional follow-up surveys planned 18 months apart.
Main Results:
- High levels of HIV care engagement and treatment success observed in baseline data.
- 95% of participants received antiretroviral therapy, and 90% achieved viral suppression.
- Persistent disparities in HIV treatment outcomes identified based on age, injection drug use, and housing stability.
Conclusions:
- While the program shows success, targeted interventions are needed for marginalized groups facing care disparities.
- Further research will explore evolving engagement in HIV care over time.
- A qualitative component will investigate experiences of treatment engagement and re-engagement.
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