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Related Experiment Video

Updated: Dec 21, 2025

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
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Host-Directed Antiviral Therapy.

Naveen Kumar1, Shalini Sharma2, Ram Kumar3

  • 1Virology Laboratory, National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, Haryana, India naveenkumar.icar@gmail.com ssharma3@vols.utk.edu.

Clinical Microbiology Reviews
|May 15, 2020
PubMed
Summary
This summary is machine-generated.

Novel antiviral drug development focuses on host-directed therapies to overcome resistance. Targeting cellular factors essential for viruses, but not hosts, offers a promising strategy against rapidly mutating viruses.

Keywords:
antiviral agentsdrug resistanceepigenetic regulationhost factorsprecision medicine

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Area of Science:

  • Virology
  • Drug Discovery
  • Molecular Biology

Background:

  • Traditional antiviral drug development targets essential viral components, often leading to rapid drug resistance.
  • Genome-wide approaches have identified host cellular factors crucial for viral replication.

Purpose of the Study:

  • To review novel antiviral drug development strategies focusing on host-directed therapies.
  • To explore potential mechanisms of antiviral drug resistance against host-targeted agents.

Main Methods:

  • Review of genome-wide approaches (siRNA, CRISPR, chemical inhibitors) to identify host factors.
  • Analysis of host-directed therapeutic strategies including immune potentiation and epigenetic modulation.

Main Results:

  • Host factors dispensable for the host but critical for viruses represent novel antiviral targets.
  • Host-directed therapies minimize resistance development compared to targeting viral components directly.

Conclusions:

  • Host-directed antiviral strategies offer a promising avenue to combat drug-resistant viruses.
  • Understanding resistance mechanisms against host-targeted agents is crucial for long-term efficacy.