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Updated: Dec 21, 2025

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

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Predictors, incidence, and prognostic significance of PR interval prolongation in patients with ST-segment elevation

Yuzhou Xue1, Jian Shen, Gang Liu

  • 1Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Coronary Artery Disease
|May 15, 2020
PubMed

Insights

PR interval prolongation in ST-segment elevation myocardial infarction (STEMI) patients during hospitalization predicts worse long-term outcomes. This finding highlights the importance of monitoring PR intervals for patient prognosis.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Clinical Medicine

Background:

  • The prognostic significance of PR interval prolongation in acute ST-segment elevation myocardial infarction (STEMI) patients remains unclear.
  • Understanding predictors and outcomes of PR interval prolongation is crucial for post-STEMI patient management.

Purpose of the Study:

  • To investigate the prevalence, predictors, and long-term prognostic impact of PR interval prolongation in a prospective cohort of STEMI patients.
  • To identify factors associated with the development of first-degree atrioventricular block post-STEMI.

Main Methods:

  • Prospective cohort study of 915 STEMI patients.
  • PR interval prolongation defined as >200 ms.
  • Multivariable logistic regression and Cox regression analyses were used to identify predictors and assess outcomes.

Main Results:

  • 9.5% of STEMI patients developed PR interval prolongation.
  • Lower ionized calcium, older age, and male sex were associated with PR prolongation.
  • PR interval prolongation independently predicted poorer long-term outcomes (HR 5.37, P=0.002) after a median follow-up of 31 months.

Conclusions:

  • PR interval prolongation is a significant independent predictor of long-term mortality in STEMI patients.
  • Monitoring PR intervals during hospitalization may aid in risk stratification for STEMI survivors.
Abstract

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