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Published on: December 2, 2016
Patients with elevated blood pressure or stage 1 hypertension have structural heart disease
Reyan Ghany1, Ana Palacio2,3, Gordon Chen1
1Department of Medicine, Chen Neighborhood Medical Centers.
Insights
New hypertension guidelines may identify more patients with structural heart disease. Echocardiograms can help risk-stratify individuals with elevated blood pressure or stage 1 hypertension for targeted treatment.
Area of Science:
- Cardiology
- Cardiovascular Medicine
- Diagnostic Imaging
Background:
- The 2017 ACC/AHA guidelines lowered the hypertension threshold to 130/80 mmHg.
- Treatment is now recommended for high-risk patients based on new categories.
Purpose of the Study:
- To assess the association between new blood pressure categories and left ventricular (LV) structural changes.
- To determine if echocardiograms aid in risk stratification and treatment initiation for hypertension.
Main Methods:
- A cross-sectional study involving 16,650 primary care patients who underwent screening echocardiograms.
- Patients were categorized by blood pressure: normal, elevated, stage 1, or stage 2 hypertension.
- Structural heart disease defined as LV hypertrophy and abnormal LV mass index; Framingham score used for risk assessment.
Main Results:
- Elevated blood pressure (OR 1.30) and stage 1 hypertension (OR 1.69) were associated with structural heart disease.
- Among 542 patients with stage 1 hypertension and low/intermediate Framingham score, 19% had structural heart disease.
Conclusions:
- A significant proportion of patients with elevated blood pressure or stage 1 hypertension exhibit structural heart disease.
- Screening echocardiograms may be valuable for risk stratification in patients not meeting traditional treatment criteria.
Background:
The 2017 American College of Cardiology (ACC) and the American Heart Association (AHA) recommendations lower the hypertension threshold to 130/80 mmHg and recommends treatment for high-risk patients. Our aim is to determine whether the new blood pressure categories are associated with left ventricular (LV) structural changes and whether echocardiograms can provide risk stratification and help treatment initiation.
Methods:
We conducted a cross-sectional study and performed screening echocardiograms to consecutive primary care patients. We calculated the Framingham score to identify patients with a low or intermediate score who had structural heart disease.We classified everyone as having normal, elevated blood pressure, stage 1 or stage 2 hypertension according to the 2017 ACC/AHA guidelines. We defined structural heart disease as having LV hypertrophy and an abnormal LV mass index.
Results:
We included 16 650 patients who underwent a screening echocardiogram and had recorded blood pressure. Out of the 16 650 patients, 1465 patients had a normal blood pressure, 1382 had elevated blood pressure, 1333 had stage 1 hypertension, and the remainder had stage 2 hypertension. The adjusted odds ratios of having structural heart disease for elevated blood pressure and stage 1 hypertension were 1.30; 95% CI, 1.112-1.64; P < 0.01 and 1.69; 95% CI, 1.25-2.30; P < 0.01, respectively. We identified 542 patients with stage 1 hypertension who had a low or intermediate Framingham score and 19% (95% CI, 16-23%) had structural heart disease.
Conclusion:
A quarter of patients identified as having elevated blood pressure or stage 1 hypertension have structural heart disease. Screening echocardiograms may help to risk stratify those patients deemed ineligible for treatment.
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