Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional Outcomes After Buddy Tape Immobilization in a Healthy Population.

Journal of hand surgery global online·2026

Same author

Patellar Osteochondral Allograft Transplantation Yields Clinically Meaningful Improvement in 2-Year Patient-Reported Outcomes.

Arthroscopy, sports medicine, and rehabilitation·2026

Same author

Ulnohumeral Joint Space Gapping Restoration to Normal on Postoperative Stress Ultrasound after Ulnar Collateral Ligament Reconstruction.

The American journal of sports medicine·2026

Same author

The Proximal Humerus Ossification System Predicts Surgical Curve Progression in Unbraced Patients With Adolescent Idiopathic Scoliosis.

Journal of pediatric orthopedics·2025

Same author

Does the Timing of Lysis of Adhesions After Anterior Cruciate Ligament Reconstruction Affect Final Range of Motion?

The American journal of sports medicine·2025

Same author

Reply to letter re: "Racial disparities in patients with amputation in an acute care setting in the immediate postoperative period".

PM & R : the journal of injury, function, and rehabilitation·2025

Same journal

Response to "Intraoperative Duplex Ultrasonography in the Pink Pulseless Hand: A Useful Adjunct, But Not Yet a Decision-Making Standard".

Journal of pediatric orthopedics·2026

Same journal

Pediatric Nonscaphoid Carpal Fractures: Fracture Distribution and Operative Management in an Institutional Cohort and 2 National EHR Databases.

Journal of pediatric orthopedics·2026

Same journal

Osteosynthesis With Barrel-Bone Grafting Technique for Failed Recalcitrant Cases of Congenital Pseudarthrosis of Tibia: Outcomes and Complications in a Series of 17 Patients.

Journal of pediatric orthopedics·2026

Same journal

The Relationship Between Screw Placement and Southwick Angle Remodeling in Slipped Capital Femoral Epiphysis.

Journal of pediatric orthopedics·2026

Same journal

Characteristics of Hip Dysplasia in Adults With Cerebral Palsy.

Journal of pediatric orthopedics·2026

Same journal

Long-term Follow-up of Myelomeningocele Patients: Factors That Can Affect Their Walking Ability.

Journal of pediatric orthopedics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 21, 2025

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Predicting Growth Quantitatively Through Proximal Tibia Radiograph Markers.

Joseph B Kahan¹, Don T Li^1,2, Christopher A Schneble¹

¹Departments of Orthopaedics and Rehabilitation.

Journal of Pediatric Orthopedics

|May 15, 2020

Summary

This summary is machine-generated.

This study introduces three new radiographic measurements of the proximal tibia to accurately assess skeletal maturity. These measurements, when combined, provide a reliable method for predicting remaining growth in children and adolescents.

More Related Videos

Culturing and Measuring Fetal and Newborn Murine Long Bones

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

Related Experiment Videos

Last Updated: Dec 21, 2025

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Culturing and Measuring Fetal and Newborn Murine Long Bones

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

Area of Science:

Orthopaedic surgery
Radiographic assessment
Skeletal maturity evaluation

Background:

Accurate skeletal maturity markers are crucial for managing pediatric orthopaedic conditions like scoliosis and leg length discrepancy.
Existing radiographic systems lack specific parameters for assessing proximal tibial growth.
This study addresses the need for quantitative methods to evaluate skeletal maturity in the proximal tibia.

Purpose of the Study:

To establish quantitative radiographic parameters within the proximal tibia for assessing skeletal maturity.
To develop a reliable method for predicting remaining growth using proximal tibial measurements.

Main Methods:

Serial radiographs and physical examinations of 94 children (ages 3-18) from the Bolton Brush collection were analyzed.
Measurements of tibial epiphysis width, tibial metaphysis width, and lateral tibial epiphysis height were correlated with remaining growth.
Regression models and inter/intraobserver reliability studies (intraclass correlation coefficient) were conducted.

Main Results:

Tibial epiphysis width, tibial metaphysis width, and lateral tibial epiphysis height showed strong correlations with remaining growth (R values 0.57-0.84).
Ratios derived from these measurements demonstrated high reliability (intraobserver ICC 0.92-0.94, interobserver ICC 0.80-0.94).
A combined multiple linear regression model achieved a predictive R value of 0.917, indicating high accuracy independent of sex.

Conclusions:

Three easily obtainable radiographic measurements of the proximal tibia, when used in ratios, reliably correlate with remaining growth.
This quantitative technique offers an improved, sex-independent method for assessing skeletal maturity from lower extremity radiographs.
The findings can inform management of various pediatric orthopaedic conditions requiring growth prediction.