Related Experiment Video
Updated: Dec 21, 2025
Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
Targeted molecular imaging of head and neck squamous cell carcinoma: a window into precision medicine
Jun Wu1, Ying Yuan, Xiao-Feng Tao
1Department of Radiology, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
Abstract:
Tumor biomarkers play important roles in tumor growth, invasion, and metastasis. Imaging of specific biomarkers will help to understand different biological activities, thereby achieving precise medicine for each head and neck squamous cell carcinoma (HNSCC) patient. Here, we describe various molecular targets and molecular imaging modalities for HNSCC imaging. An extensive search was undertaken in the PubMed database with the keywords including "HNSCC," "molecular imaging," "biomarker," and "multimodal imaging." Imaging targets in HNSCC consist of the epidermal growth factor receptor, cluster of differentiation 44 variant 6 (CD44v6), and mesenchymal-epithelial transition factor and integrins. Targeted molecular imaging modalities in HNSCC include optical imaging, ultrasound, magnetic resonance imaging, positron emission tomography, and single-photon emission computed tomography. Making the most of each single imaging method, targeted multimodal imaging has a great potential in the accurate diagnosis and therapy of HNSCC. By visualizing tumor biomarkers at cellular and molecular levels in vivo, targeted molecular imaging can be used to identify specific genetic and metabolic aberrations, thereby accelerating personalized treatment development for HNSCC patients.
Insights
Molecular imaging targets specific biomarkers in head and neck squamous cell carcinoma (HNSCC) to guide precise medicine. Multimodal imaging offers potential for accurate HNSCC diagnosis and therapy.
Area of Science:
- Oncology
- Medical Imaging
- Biochemistry
Background:
- Tumor biomarkers are crucial for understanding head and neck squamous cell carcinoma (HNSCC) progression.
- Precise medicine in HNSCC requires understanding individual tumor biology through imaging.
Purpose of the Study:
- To review molecular targets and imaging modalities for HNSCC.
- To highlight the potential of targeted multimodal imaging for HNSCC diagnosis and treatment.
Main Methods:
- PubMed database search using keywords: "HNSCC," "molecular imaging," "biomarker," and "multimodal imaging."
- Identification of key imaging targets and modalities relevant to HNSCC.
Main Results:
- Key HNSCC imaging targets include epidermal growth factor receptor, CD44v6, and integrins.
- Modalities encompass optical imaging, ultrasound, MRI, PET, and SPECT.
- Targeted multimodal imaging shows promise for HNSCC diagnosis and therapy.
Conclusions:
- Visualizing biomarkers in vivo aids in identifying genetic and metabolic aberrations in HNSCC.
- Targeted molecular imaging accelerates personalized treatment development for HNSCC patients.
More Related Videos
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
06:54MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
